Job Description
Responsibilities for this Position
Location: USA MD Silver Spring
Full Part/Time: Full time
Job Req: RQ194765
Type of Requisition: Regular
Clearance Level Must Currently Possess: None
Clearance Level Must Be Able to Obtain: None
Public Trust/Other Required: NACLC (T3)
Job Family: Scientists
Job Qualifications: Skills: ADME, High-Performance Liquid Chromatography (HPLC), Mass Spectrometry (MS)
Certifications: None
Experience: 2 + years of related experience
US Citizenship Required: Yes
Job Description: GDIT is seeking a Bioanalytical Scientist to support the Walter Reed Army institute of Research's Experimental Therapeutics Branch. This position will support the research and any activities needed to most efficiently advance lead candidate drugs to the next level of testing and ultimately FDA approval. HOW YOU WILL MAKE AN IMPACT: - Assist with the development and validation of analytical methods for the identification of candidate new drugs and putative metabolites using HPLC with UV/VIS, radioactive monitor analyses, and/or mass spectrometry as needed.
- Assist with the characterization of metabolites formation and metabolic profiles of candidate drugs using in vivo and in vitro techniques as needed. Prepare samples to be assayed using both manual and robotic/high-throughput means.
- Use in vitro techniques (liver microsomes, hepatocytes, slices) to assess for potential metabolism-based drug-drug interactions involving hepatic P450 enzymes.
- Assist with the design and implementation of cytotoxicity and permeability studies involving the use of cell cultures under aseptic techniques.
- Maintain and troubleshoot HPLC and mass spectrometry systems, a robotic liquid handling system, and basic pharmacology/toxicology laboratory equipment.
- Maintain appropriate data records and notebooks.
- Prepare biological samples for analysis using methods to include tissue homogenization, blood spot filter puncture, and solvent extraction.
- Conduct ELISA assays in support of pharmacokinetic and biomarker studies.
- Perform chemical derivatization reactions when required for analyte detection.
- Conduct in vitro assays using TECAN Liquid Handling systems.
- Assist in manual tasks including, but not limited to, filling liquid nitrogen dewars and tanks for use in laboratory operations, biohazard disposal, and acquisition/return of gas tanks from the logistics facility.
- Assist in chemical and supply inventories and laboratory organization as requested.
- Present novel laboratory findings at a nationally recognized scientific meeting and submit for publication in peer-reviewed journals.
- Assist with the initiation and tracking of purchase request, and service calls through Medical Maintenance Branch.
- Comply with all specified guidelines regarding safety, security, standard operating procedures, written protocols, technical manuals, and procurement of supplies/equipment as per WRAIR regulations
WHAT YOU'LL NEED TO SUCCEED: - BS in Chemistry, Biology, or related field with relevant bioanalytical coursework
- 2+ years of experience analytical chemistry
- Working knowledge of HPLC analysis and familiarity with the handling of biological samples.
- Experience to perform hands-on laboratory ADME assays, such as microsomal metabolic stability, water solubility and cell permeability.
- Experience with metabolism related studies, along with troubleshooting and basic maintenance of mass spectrometry equipment
- Experience with basic MS Office (or compatible) software for generating reports and summaries for presentations, managing data spreadsheets, requesting supplies and materiel as needed to perform general laboratory maintenance.
- Excellent organizational and interpersonal skills as well as good written and oral communication.
- Must be a US citizen with the ability to obtain a favorable NACI T1 security investigation.
WHAT GDIT CAN OFFER YOU: - 401K with company match
- Customizable health benefits packages
- Internal mobility team dedicated to helping you own your career
- Challenging work that makes a real impact on the world around you
- Full-flex work week
#GDITHealth #GDITFedHealth #GDITLabScienceJobs #MilitaryHealthGDITJobs The likely salary range for this position is $52,270 - $66,700. This is not, however, a guarantee of compensation or salary. Rather, salary will be set based on experience, geographic location and possibly contractual requirements and could fall outside of this range.
Scheduled Weekly Hours: 40
Travel Required: Less than 10%
Telecommuting Options: Onsite
Work Location: USA MD Silver Spring
Additional Work Locations: Total Rewards at GDIT: Our benefits package for all US-based employees includes a variety of medical plan options, some with Health Savings Accounts, dental plan options, a vision plan, and a 401(k) plan offering the ability to contribute both pre and post-tax dollars up to the IRS annual limits and receive a company match. To encourage work/life balance, GDIT offers employees full flex work weeks where possible and a variety of paid time off plans, including vacation, sick and personal time, holidays, paid parental, military, bereavement and jury duty leave. To ensure our employees are able to protect their income, other offerings such as short and long-term disability benefits, life, accidental death and dismemberment, personal accident, critical illness and business travel and accident insurance are provided or available. We regularly review our Total Rewards package to ensure our offerings are competitive and reflect what our employees have told us they value most.
We are GDIT. A global technology and professional services company that delivers consulting, technology and mission services to every major agency across the U.S. government, defense and intelligence community. Our 30,000 experts extract the power of technology to create immediate value and deliver solutions at the edge of innovation. We operate across 30 countries worldwide, offering leading capabilities in digital modernization, AI/ML, Cloud, Cyber and application development. Together with our clients, we strive to create a safer, smarter world by harnessing the power of deep expertise and advanced technology.
We connect people with the most impactful client missions, creating an unparalleled work experience that allows them to see their impact every day. We create opportunities for our people to lead and learn simultaneously. From securing our nation's most sensitive systems, to enabling digital transformation and cloud adoption, our people are the ones who make change real.
Equal Opportunity Employer / Individuals with Disabilities / Protected Veterans
PI265502436
GDIT is seeking a Bioanalytical Scientist to support the Walter Reed Army institute of Research's Experimental Therapeutics Branch. This position will support the research and any activities needed to most efficiently advance lead candidate drugs to the next level of testing and ultimately FDA approval. HOW YOU WILL MAKE AN IMPACT: - Assist with the development and validation of analytical methods for the identification of candidate new drugs and putative metabolites using HPLC with UV/VIS, radioactive monitor analyses, and/or mass spectrometry as needed.
- Assist with the characterization of metabolites formation and metabolic profiles of candidate drugs using in vivo and in vitro techniques as needed. Prepare samples to be assayed using both manual and robotic/high-throughput means.
- Use in vitro techniques (liver microsomes, hepatocytes, slices) to assess for potential metabolism-based drug-drug interactions involving hepatic P450 enzymes.
- Assist with the design and implementation of cytotoxicity and permeability studies involving the use of cell cultures under aseptic techniques.
- Maintain and troubleshoot HPLC and mass spectrometry systems, a robotic liquid handling system, and basic pharmacology/toxicology laboratory equipment.
- Maintain appropriate data records and notebooks.
- Prepare biological samples for analysis using methods to include tissue homogenization, blood spot filter puncture, and solvent extraction.
- Conduct ELISA assays in support of pharmacokinetic and biomarker studies.
- Perform chemical derivatization reactions when required for analyte detection.
- Conduct in vitro assays using TECAN Liquid Handling systems.
- Assist in manual tasks including, but not limited to, filling liquid nitrogen dewars and tanks for use in laboratory operations, biohazard disposal, and acquisition/return of gas tanks from the logistics facility.
- Assist in chemical and supply inventories and laboratory organization as requested.
- Present novel laboratory findings at a nationally recognized scientific meeting and submit for publication in peer-reviewed journals.
- Assist with the initiation and tracking of purchase request, and service calls through Medical Maintenance Branch.
- Comply with all specified guidelines regarding safety, security, standard operating procedures, written protocols, technical manuals, and procurement of supplies/equipment as per WRAIR regulations
WHAT YOU'LL NEED TO SUCCEED: - BS in Chemistry, Biology, or related field with relevant bioanalytical coursework
- 2+ years of experience analytical chemistry
- Working knowledge of HPLC analysis and familiarity with the handling of biological samples.
- Experience to perform hands-on laboratory ADME assays, such as microsomal metabolic stability, water solubility and cell permeability.
- Experience with metabolism related studies, along with troubleshooting and basic maintenance of mass spectrometry equipment
- Experience with basic MS Office (or compatible) software for generating reports and summaries for presentations, managing data spreadsheets, requesting supplies and materiel as needed to perform general laboratory maintenance.
- Excellent organizational and interpersonal skills as well as good written and oral communication.
- Must be a US citizen with the ability to obtain a favorable NACI T1 security investigation.
WHAT GDIT CAN OFFER YOU: - 401K with company match
- Customizable health benefits packages
- Internal mobility team dedicated to helping you own your career
- Challenging work that makes a real impact on the world around you
- Full-flex work week
Job Tags
Holiday work, Full time, Temporary work, Part time, Work experience placement, Immediate start, Remote job, Worldwide, Flexible hours,